First of. all, it's absolutely worthy & important as a primary and utmost concern for any antipsychotics users to seriously take precautionary notes, concerns and cautions that -

“Use of antipsychotics is associated with reductions in brain tissue volumes,
[104] , [105] including  White matter reduction, [106] an effect which is dose-dependent and time-dependent."

as quoted from :  Antipsychotic

Note : Multiple high-quality scientific findings and research papers are contained in these quotations [104], [105] and [106]

Primary concern for antipsychotics users - Brain tissues losses & cognitive impairments


Further scientific details as a follow-up of the above -


“Taken together, these studies suggest that antipsychotics may contribute to early gray matter loss and, later in the course of treatment, to white matter loss. These effects may be dose-related and probably are not prevented by the use of second-generation agents. This argues for minimizing antipsychotic exposure both acutely and long term”

as quoted from :


https://www.psychiatrictimes.com/view/antipsychotics-and-shrinking-brain - Antipsychotics and the Shrinking Brain


https://en.wikipedia.org/wiki/Grey_matter - Grey matter


https://en.wikipedia.org/wiki/White_matter - White matter


“Subjective cognitive impairment, particularly cognitive slowing, is commonly reported by people taking antipsychotics. Naturalistic studies have shown higher cumulative antipsychotic exposure to be associated with poorer cognitive functioning”

as quoted from :


https://www.nature.com/articles/s41380-024-02503-x

- Advancing understanding of the mechanisms of antipsychotic-associated cognitive impairment to minimise harm: a call to action


https://en.wikipedia.org/wiki/Cognitive_impairment - Cognitive impairment


Whilst in the worst-case scenario,


“Exposure to any antipsychotics (APs) conferred increased risks of dementia. Cumulative dose-response relationships between oral APs and dementia risk existed. Both typical and atypical APs increased dementia risk with different effect sizes. The results were robust across a range of sensitivity analyses.”

Source :

Associations between antipsychotics exposure and dementia risk

https://en.wikipedia.org/wiki/Dementia - Dementia


Note :

The scientific findings highlighted above can be easily observed, cross-evidenced, examined & verified in real life by the time-after-time progressively perceived mental conditions of, especially among the ones aging 50s and above taking Antipsychotics consistently for over 10 years.

List of long term side effects of antipsychotics


Follow-up -

Other untold & Deliberately Con...tagonist / Antipsychotics / Neuroleptics



Others -


Primary concern for antipsychotics users - Brain tissues losses & cognitive impairments


Primary concern for antipsychotics users - The worst-case scenario

List of long term side effects of antipsychotics


Fees-seeking Psychiatrist & Th...r Personal Heath Cares & Well-beings


Follow-up - General & brief idea about psychotherapy