It's hard to be exact about how far to distance Algin from other supplements because there are many factors involved, plus, it's different for everyone.

I use this rule that has worked well for me. Take Algin at least 1 hour before or 1 hour after any other supplements. I also typically space it between meals UNLESS you're trying to protect yourself from something you're eating.

For example, I love salmon but get mercury symptoms starting within an hour after eating it. If I take 4 algin about 30 minutes before eating and 30 minutes after eating it, I have no mercury symptoms at all. I'll then take Algin again before bed that night for an extra measure of protection.

Hope this helps.