Before the switch to synthetics, I was up to 6 grains of Armour. I still suffered from extreme fatigue, brain fog (so bad I couldn't drive a car in the afternoon) Hand pain, the hashimoto's was out of control. I couldn't breathe, or I call it air deprevation. Periods were heavy and painful, low body temp. I had it all. I feel about 50% better on levoxyl and cytomel than the armour.