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Joined: Dec 1999
Posts: 30,867
Master Elite Member
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I'm sorry to hear about this situation. This must be a little frightening. Please let us know what you find out. Here is some information about this that may be interesting: When lidocaine was incubated with fresh human liver slices for four hours, 67% of the lidocaine was converted to its aniline homolog, 2,6-dimethylaniline, an established animal and probable human carcinogen 12,13. A second study published that same year demonstrated significantly elevated human hemoglobin adduct levels of 2,6-dimethylaniline in patients who had received lidocaine in accepted clinical treatment for cardiac problems 16. The FDA ruled that the package insert for EMLA, a dermatologic cream containing lidocaine and prilocaine, would contain this warning: "Metabolites of both lidocaine and prilocaine have been shown to be carcinogenic in animals...The [ortho-toluidine induced] tumors included hepatocarcinomas/adenomas in female mice, multiple occurences of hemangiosarcomas/ hemangiomas in both sexes of mice, sarcomas of multiple organs, transitional cell carcinomas/papillomas of urinary bladder in both sexes of rats, subcutaneous fibromas/ fibrosarcomas and mesotheliomas in male rats, and mammary gland fibroadenomas/adenomas in female rats. The lowest dose tested (900 mg/m ; 60 times SDA) was carcinogenic in both species. Source: http://www.heall.com/body/healthupdates/dentistry/almagam.html
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