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<p><a name="t1"></a>
Table 1. Thimerosal Content of Vaccines Routinely Recommended for Children 6 Years of Age and Younger - <em>(updated 7/18/2005*)<br>
*Since this update, a biologics license application was approved for Rotavirus Vaccine, Tradename-RotaTeq (Merck), that is thimerosal free and never contained thimerosal.</em> </p>
<table border="1" cellspacing="1" cellpadding="9" width="98%" summary="Thimerosal Content of Vaccines Routinely Recommended for Children 6 Years of Age and Younger">
<tr bgcolor="#DADADA" valign="top">
<th width="25%" scope="col">Vaccine</th>
<th width="25%" scope="col">Tradename<br>
(Manufacturer)</th>
<th width="25%" scope="col">Thimerosal Status Concentration**(Mercury)</th>
<th width="25%" scope="col">Approval Date for Thimerosal Free or Thimerosal / Preservative Free (Trace Thimerosal)*** Formulation</th>
</tr>
<tr valign="top">
<td rowspan="3">DTaP</td>
<td>Infanrix<br>
(GlaxoSmithKline Biologicals)</td>
<td>Free</td>
<td>Never contained more than a trace of thimerosal, approval date for thimerosal-free formulation 9/29/2000</td>
</tr>
<tr valign="top">
<td>Daptacel<br>
(Sanofi Pasteur, Ltd)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>Tripedia<br>
(Sanofi Pasteur, Inc)</td>
<td>Trace(≤0.3 µg Hg/0.5mL dose)</td>
<td>03/07/01</td>
</tr>
<tr valign="top">
<td>DTaP-HepB-IPV</td>
<td>Pediarix<br>
(GlaxoSmithKline Biologicals)</td>
<td>Free</td>
<td>Never contained more than a Trace of Thimerosal, approval date for thimerosal-free formulation 1/29/2007 </td>
</tr>
<tr valign="top">
<td>Pneumococcal conjugate</td>
<td>Prevnar<br>
(Wyeth Pharmaceuticals Inc)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>Inactivated Poliovirus</td>
<td>IPOL<br>
(Sanofi Pasteur, SA)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>Varicella (chicken pox)</td>
<td>Varivax<br>
(Merck & Co, Inc)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>Mumps, measles, and rubella</td>
<td>M-M-R-II<br>
(Merck & Co, Inc)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td rowspan=2>Hepatitis B</td>
<td>Recombivax HB<br>
(Merck & Co, Inc)</td>
<td>Free</td>
<td>08/27/99</td>
</tr>
<tr valign="top">
<td>Engerix B<br>
(GlaxoSmithKline Biologicals)</td>
<td>Free</td>
<td>03/28/00, approval date for thimerosal-free formulation 1/30/2007 </td>
</tr>
<tr valign="top">
<td rowspan="3">Haemophilus influenzae type b conjugate (Hib)</td>
<td>ActHIB<br>
(Sanofi Pasteur, SA)<br>
OmniHIB<br>
(GlaxoSmithKline)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>PedvaxHIB<br>
(Merck & Co, Inc)</td>
<td>Free</td>
<td>08/99</td>
</tr>
<tr valign="top">
<td>HibTITER, single dose<br>
(Wyeth Pharmaceuticals, Inc.)<sup>1</sup></td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td>Hib/Hepatitis B combination</td>
<td>Comvax<br>
(Merck & Co, Inc)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
<tr valign="top">
<td rowspan="4">Influenza</td>
<td>Fluzone<br>
(Sanofi Pasteur, Inc)</td>
<td>0.01% (12.5 µg/0.25 mL dose, 25 µg/0.5 mL dose)<sup>2</sup></td>
<td> </td>
</tr>
<tr valign="top">
<td>Fluzone<br>
(Sanofi Pasteur, Inc)<sup>3</sup><br>
(no thimerosal)</td>
<td>Free</td>
<td>12/23/2004</td>
</tr>
<tr valign="top">
<td>Fluvirin<br>
(Novartis Vaccines and Diagnostics Ltd)</td>
<td>0.01% (25 µg/0.5 mL dose)</td>
<td> </td>
</tr>
<tr valign="top">
<td>Fluvirin<br>
(Novartis Vaccines and Diagnostics Ltd)<br>
(Preservative Free)</td>
<td>Trace (<1ug Hg/0.5mL dose)</td>
<td>09/28/01</td>
</tr>
<tr valign="top">
<td>Influenza, live</td>
<td>FluMist<sup>4<br>
</sup>(MedImmune Vaccines, Inc)</td>
<td>Free</td>
<td>Never contained Thimerosal</td>
</tr>
</table>
<p>
** Thimerosal is approximately 50% mercury (Hg) by weight. A 0.01% solution (1 part per 10,000) of thimerosal contains 50 µg of Hg per 1 mL dose or 25 µg of Hg per 0.5 mL dose.<br>
*** The term "trace" has been taken in this context to mean 1 microgram of mercury per dose or less.<br>
1 HibTiITER was also manufactured in thimerosal-preservative containing multidose vials but these were no longer available after 2002.<br>
2 Children 6 months old to less than 3 years of age receive a half-dose of vaccine, i.e., 0.25 mL; children 3 years of age and older receive 0.5 mL.<br>
3 A trace thimerosal containing formulation of Fluzone was approved on 9/14/02 and has been replaced with the formulation without thimerosal.<br>
4 FluMist is not indicated for children less than 5 years of age.</p>
<p><a href="#toc">Table of Contents</a></p>
<hr>
<p><a name="t2"></a>
Table 2: Preservatives Used in U.S. Licensed Vaccines</p>
<table border="1" cellspacing="1" cellpadding="9" width="98%" summary="Preservatives Used in U.S. Licensed Vaccines">
<tr bgcolor="#DADADA" valign="top">
<th scope="col" width="41%">Preservative</th>
<th scope="col" width="59%">Vaccine Examples (Tradename; Manufacturer)</th>
</tr>
<tr valign="top">
<td>Thimerosal</td>
<td>DT<br>
Td (several)<br>
TT (several)<br>
Influenza (several)</td>
</tr>
<tr valign="top">
<td>2-phenoxyethanol and formaldehyde </td>
<td>IPV (IPOL; Sanofi Pasteur, SA)<br>
DTaP (Daptacel; Sanofi Pasteur, Ltd)</td>
</tr>
<tr valign="top">
<td>Phenol</td>
<td>Typhoid Vi Polysaccharide (Typhim Vi; Sanofi Pasteur, SA)<br>
Pneumococcal Polysaccharide (Pneumovax 23; Merck & Co, Inc)</td>
</tr>
<tr valign="top">
<td>Benzethonium chloride (Phemerol)</td>
<td>Anthrax (Biothrax; BioPort Corporation)</td>
</tr>
<tr valign="top">
<td>2-phenoxyethanol</td>
<td>DTaP (Infanrix; GlaxoSmithKline Biologicals)<br>
Hepatitis A (Havrix; GlaxoSmithKline Biologicals)<br>
Hepatitis A/Hepatitis B (Twinrix; GlaxoSmithKline Biologicals)</td>
</tr>
</table>
<p><a href="#toc">Table of Contents</a></p>
<hr>
<p><a name="t3"></a>
Table 3: Thimerosal and Expanded List of Vaccines - <em>(updated 11/16/2006)</em><br>
Thimerosal Content in Currently Manufactured U.S. Licensed Vaccines</p>
<table border="1" cellspacing="1" cellpadding="4" width="98%" summary="Thimerosal Content in Currently Manufactured U.S. Licensed Vaccines">
<tr bgcolor="#DADADA" valign="top">
<th scope="col" width="13%">Vaccine</th>
<th scope="col" width="19%">Trade Name</th>
<th socpe="col" width="19%">Manufacturer</th>
<th scope="col" width="24%">Thimerosal Concentration<sup>1</sup></th>
<th scope="col" width="25%">Mercury</th>
</tr>
<tr valign="top">
<td>Anthrax</td>
<td>Anthrax vaccine</td>
<td>BioPort Corporation</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan="3">DTaP</td>
<td>Tripedia<sup>2</sup></td>
<td>Sanofi Pasteur, Inc</td>
<td>≤ 0.00012%</td>
<td>≤ 0.3 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td>Infanrix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Daptacel</td>
<td>Sanofi Pasteur, Ltd</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>DTaP-HepB-IPV</td>
<td>Pediarix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>DT</td>
<td rowspan=2>No Trade Name</td>
<td>Sanofi Pasteur, Inc</td>
<td>< 0.00012% (single dose)</td>
<td>< 0.3 µg/0.5mL dose</td>
</tr>
<tr valign="top">
<td>Sanofi Pasteur, Ltd<sup>3</sup></td>
<td>0.01%</td>
<td>25 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td rowspan="3">Td</td>
<td>No Trade Name</td>
<td>Mass Public Health</td>
<td>0.0033%</td>
<td>8.3 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td>Decavac</td>
<td>Sanofi Pasteur, Inc</td>
<td>≤ 0.00012%</td>
<td>≤ 0.3 µg mercury/0.5 ml dose</td>
</tr>
<tr valign="top">
<td>No Trade Name</td>
<td widht=19%>Sanofi Pasteur, Ltd</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Tdap</td>
<td>Adacel</td>
<td>Sanofi Pasteur, Ltd</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Boostrix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>TT</td>
<td>No Trade Name</td>
<td>Sanofi Pasteur, Inc</td>
<td>0.01%</td>
<td>25 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td rowspan="3">Hib</td>
<td>ActHIB/OmniHIB<sup>4</sup></td>
<td>Sanofi Pasteur, SA</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>HibTITER</td>
<td>Wyeth Pharmaceuticals, Inc.</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>PedvaxHIB liquid</td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Hib/HepB</td>
<td>COMVAX<sup>5</sup></td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Hepatitis B</td>
<td>Engerix-B<br>
Pediatric/adolescent
<p>
Adult</td>
<td>GlaxoSmithKline Biologicals
</td>
<td> <br>
< 0.0002%
<p>
< 0.0002%</td>
<td> <br>
< 0.5 µg/0.5 mL dose
<p>
<1µg/1 ml dose</td>
</tr>
<tr valign="top">
<td>Recombivax HB
<p>Pediatric/adolescent
<p>Adult (adolescent)
<p>Dialysis
</td>
<td>Merck & Co, Inc</td>
<td>
<p>0
<p>0
<p>0
</td>
<td>
<p>0
<p>0
<p>0
</td>
</tr>
<tr valign="top">
<td rowspan=2>Hepatitis A</td>
<td>Havrix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Vaqta</td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>HepA/HepB</td>
<td>Twinrix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>< 0.0002%</td>
<td>< 1 µg/1mL dose</td>
</tr>
<tr valign="top">
<td rowspan=2>IPV</td>
<td>IPOL</td>
<td>Sanofi Pasteur, SA</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Poliovax</td>
<td>Sanofi Pasteur, Ltd </td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=6>Influenza</td>
<td>Fluzone<sup>6</sup></td>
<td>Sanofi Pasteur, Inc</td>
<td>0.01%</td>
<td>25 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td>Fluvirin</td>
<td>Novartis Vaccines and Diagnostics Ltd</td>
<td>0.01%</td>
<td>25 µg/0.5 ml dose</td>
</tr>
<tr valign="top">
<td>Fluzone (no thimerosal)</td>
<td>Sanofi Pasteur, Inc</td>
<td>0</td>
<td>0</td>
<tr valign="top">
<td>Fluvirin (Preservative Free)</td>
<td>Novartis Vaccines and Diagnostics Ltd</td>
<td>< 0.0004%</td>
<td>< 1 µg/0.5 mL dose
</td>
</tr>
<tr valign="top">
<td>Fluarix</td>
<td>GlaxoSmithKline Biologicals</td>
<td>< 0.0004%</td>
<td>< 1 µg/0.5 ml dose</td>
</tr>
<tr valign="top">
<td>FluLaval</td>
<td>ID Biomedical Corporation of Quebec</td>
<td>0.01%</td>
<td>25 µg/0.5 ml dose
</td>
</tr>
<tr valign="top">
<td>Influenza, live</td>
<td>FluMist</td>
<td>MedImmune Vaccines, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Japanese Encephalitis<sup>7</sup></td>
<td>JE-VAX</td>
<td>Research Foundation for Microbial Diseases of Osaka University</td>
<td>0.007%</td>
<td>35 µg/1.0mL dose<br>
17.5 µg/0.5 mL dose</td>
</tr>
<tr valign="top">
<td>MMR</td>
<td>MMR-II</td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Meningococcal</td>
<td>Menomune A, C, AC and A/C/Y/W-135</td>
<td>Sanofi Pasteur, Inc</td>
<td>0.01% (multidose)<br>
0 (single dose)</td>
<td>25 µg/0.5 dose<br>
0</td>
</tr>
<tr valign="top">
<td>Menactra A, C, Y and W-135</td>
<td>Sanofi Pasteur, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Pneumococcal</td>
<td>Prevnar (Pneumo Conjugate)</td>
<td>Wyeth Pharmaceuticals Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Pneumovax 23</td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Rabies</td>
<td>IMOVAX</td>
<td>Sanofi Pasteur, SA</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Rabavert</td>
<td>Novartis Vaccines and Diagnostics</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td rowspan=2>Typhoid Fever</td>
<td>Typhim Vi</td>
<td>Sanofi Pasteur, SA</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Vivotif</td>
<td>Berna Biotech, Ltd</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Varicella</td>
<td>Varivax</td>
<td>Merck & Co, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td>Yellow Fever</td>
<td>Y-F-Vax</td>
<td>Sanofi Pasteur, Inc</td>
<td>0</td>
<td>0</td>
</tr>
<tr valign="top">
<td colspan="5">Table Footnotes
<ol>
[*]Thimerosal is approximately 50% mercury (Hg) by weight. A 0.01% solution (1 part per 10,000) of thimerosal contains 50 µg of Hg per 1 ml dose or 25 µg of Hg per 0.5 ml dose.</li>
[*]Sanofi Pasteur's Tripedia may be used to reconstitute ActHib to form TriHIBit. TriHIBit is indicated for use in children 15 to 18 months of age.</li>
[*]This vaccine is not marketed in the US.</li>
[*]OmniHIB is manufactured by Sanofi Pasteur but distributed by GlaxoSmithKline.</li>
[*]COMVAX is not licensed for use under 6 weeks of age because of decreased response to the Hib component.</li>
[*]Children under 3 years of age receive a half-dose of vaccine, i.e., 0.25 mL (12.5 µg mercury/dose.)</li>
[*]JE-VAX is distributed by Aventis Pasteur. Children 1 to 3 years of age receive a half-dose of vaccine, i.e., 0.5 mL (17.5 µg mercury/dose).</li>
[/LIST]
</td>
</tr>
</table>
