I was taking this last year, but after a while forgot about it and stopped taking it. Yesterday my muscle ache was intense, and I remembered that I still had plenty of creatine. I took it yesterday(one large teaspoon of the powder in a cup of water, 5 grams or so)and my muscle ache was much less after that. I took it again today, and am again feeling some relief. In case you don't know what creatine is, it is a nitrogenous organic acid that many weight lifters take to enhance muscle function. One website I read said that those with CFS have higher than normal creatine excretion.

"CFS and Fibromyalgia patients have also been found to commonly have abnormal enzymatic processes that affect the sodium?potassium ATPase energy channels(473), which appears to be a major factor in the condition and for which mercury is a known cause(43,288,498). This also has been found to result in inflammatory processes that cause muscle tissue damage and result in higher levels of urinary excretion of creatine , choline, and glycine in CFS, and higher levels of excretion of choline, taurine, citrate, and trimethyl amine oxide in FM(474,593,594). Supplementation of creatine has been found to result in improved muscle mitochondrial function in such patients(502). "

http://www.flcv.com/cfsfm.html

http://en.wikipedia.org/wiki/Creatine