Anything that doesn't let you get a good night's sleep though imo doesn't make that much sense. I did over 20 rounds of chelation last year with ALA/DMSA, but can't use these this year due to sleep problems(no way could I get up in the middle of the night to take a dose, then fall back to sleep). I am trying a regimen now with 48 mg a day of iodine, and cilantro. Cutler says iodine doesn't help get rid of mercury, however a number of others disagree with him on this, and point to studies of increased urine mercury levels with high iodine intake.

The Cutler protocol is one detox method, however it might not be appropriate for everyone all the time. If decent timed release ALA and DMSA would be devised, and it would only be necessary to take it 3x a day, then it would be much simpler.