A breakdown in the Blood Brain Barrier are common events following physical trauma to the central nervous system or following autoimmune disease..

http://www.ncbi.nlm.nih.gov/pubmed/10375654

and ensuing gliosis got to look that up.

endothelial cell tight junctions and the BBB..
Chronic Inflammatory Pain leads too.
And increased permeability.

Also in M.S and inflammatory CNS disorders

http://ajpheart.physiology.org/cgi/content/full/289/2/H738

Serum Autoantibodies To Brain in LKS Varient, Autism and other Neurological disorders.

http://www.icdrc.org/documents/Anne%20Connolly%20article%201.pdf

IGM Immunostaining To Brain Endothelial Cells

The common threads what does this mean??