Welcome to Friends of Landau Kleffner Syndrome!

Folks!

http://www.friendsoflks.com/

What is LKS?

The frustration, hitting, being punched or even bitten, head banging fits of rage.
Behavior issues with limited speech or no speech at all.
Hypersensitivity and aggression can accompany this disorder.
Think of the sensation of being locked in without any clue how to get out.
" snatches of memory and sensation a regressive disorder that can rob one of speech and memory.
Imagine that one day you were unable to connect with your loved ones with spoken language.
Think of the feeling of being locked in without any clue how to get out.
Think of the anxiety and frustration that you would feel.
This is what these children go through.

Metabolic Abnormalities..

http://jcn.sagepub.com/cgi/content/abstract/12/8/489

http://www.infantile-spasms.org/

It is well known that children on the autistic spectrum can also undergo a simular regression and have EGG findings simular to those found in LKS patients.
Language regression ect..

Also IGM immunostaining has been described in some children with LKS varient and Autism.

I think this is related a form of autism maybe a more severe form so simular it's probably from the same cause of what caused the autism but maybe worse of an reaction a condition.

Inflammation Autoimmune Antibodies that can be made against your own tissues your brain.
Brain Endothelial Cells.

IGM: IgM antibodies are the type that form when an infection occurs for the first time, high levels of IgM can indicate a new infection is present.

They are found in blood and lymph fluid and are the first type of antibody made in response to an infection.

High levels of IgM can indicate macroglobulinemia, early viral hepatitis, mononucleosis, rheumatoid arthritis, kidney damage (nephrotic syndrome), or a parasite infection.

They also cause other immune system cells to destroy foreign substances.

It seems they came about in a response to an infection.
An immune response.

Plus...
Impaired growth and delayed pubertal development are often described in chronic inflammatory diseases.
Could be protein malnutrition due to malabsorption...

autoimmune demyelinative neuropathy patients
Blood nerve barrier..

http://www.neurology.org/cgi/content/abstract/54/7/1459

Guillain-Barré leakage in blood–nerve barrier
Destruction or malfunction

http://www.neurology.org/cgi/content/abstract/60/2/301

This is serious..
An inflammation of the blood brain barrier an autoimmune disorder in the brain.

Antibodies made in response to an infection..
What type of infection is the body responding to that caused this response to go haywire.
A hightened immune response..
So how does one stop the attack on ones brain?

A breakdown in the Blood Brain Barrier are common events following physical trauma to the central nervous system or following autoimmune disease..

http://www.ncbi.nlm.nih.gov/pubmed/10375654

and ensuing gliosis got to look that up.

endothelial cell tight junctions and the BBB..
Chronic Inflammatory Pain leads too.
And increased permeability.

Also in M.S and inflammatory CNS disorders

http://ajpheart.physiology.org/cgi/content/full/289/2/H738

Serum Autoantibodies To Brain in LKS Varient, Autism and other Neurological disorders.

http://www.icdrc.org/documents/Anne%20Connolly%20article%201.pdf

IGM Immunostaining To Brain Endothelial Cells

The common threads what does this mean??

Disabled World
Disability and Health News

List of Neurological Disorders.
There's just so many of them...

http://www.disabled-world.com/artman/publish/neurological-disorders-list.shtml

Blood Brain Barrier damage in MS annd also Alterations of BBB in Alzheimer's.. Cerebrovascular..
The BBB in Neuroinflammatory Disease's..

http://brain.oxfordjournals.org/cgi/content/abstract/114/1/557

IgG in brain ... HTLV-1 associated neurologic disease

http://www.neurology.org/cgi/content/abstract/60/8/1320

Landau–Kleffner syndrome plus links..

http://en.wikipedia.org/wiki/Landau-Kleffner_syndrome

Inflammatory Brain Changes in Lyme..

http://brain.oxfordjournals.org/cgi/content/abstract/119/6/2143

Blood Brain Barrier dysfunction is frequent..
Lyme...

http://www.jstor.org/pss/30129579

Blood Brain Barrier and Diseases involving the Blood-Brain Barrier..

http://en.wikipedia.org/wiki/Blood-brain_barrier
disruption of the BBB by either artificial or inflammatory mechanisms..
In seizures..

De Vivo disease 1991 first diagnoised..
http://en.wikipedia.org/wiki/De_Vivo_disease

http://ghr.nlm.nih.gov/condition=glut1deficiencysyndrome

Lots of neuroinflammation going on out there.

http://www.newautismcure.com/category/autism-treatment/

Seizures are also a very common symptom of Pervasive Development Disorders (PDD) including Autism.
Specifically in Autism, auditory hypersensitivity is very common and can be extremely painful.
Another similar condition, Hyperacusis is common in Autism.

Neuroinflammation.. Research Center (NIRC)

http://www.lerner.ccf.org/neurosci/overview.php

Neuro- degeneration Neurological Disease..
http://www.springerlink.com/content/8164x9114420336v/

Lyme and hyperacusis and other medical conditions that can cause hyperacusis which is a symptom, not a disease.

Neuro inflammation is pretty common it seems..

Immunodeficency Diseases and HIM
IgM

I read that patients with primary immunodeficiency diseases or boys with HIM,
should not receive live virus vaccines since there is a remote possibility that the vaccine strain of the virus may cause disease.

I think there are lots of people in this world with autoimmune disorders and immune problems and many just don't know it of yet...
that could be takeing a big risk when getting vaccinated.
And it's not just about getting a disease but a disorder from the toxic ingrediants in vaccines.

http://www.immunedisease.com/patients-and-families/about-pi/types-of-pi/hyper-igm-syndrome.html

Measles Igm Response During Reinfection of Previously Vaccinated Children..

Measles Igm Antibody...

http://www.jpeds.com/article/S0022-3476(73)80069-1/abstract

Also IGM immunostaining has been described in some children with LKS varient and Autism..

IGM Immunostaining To Brain Endothelial Cells..

Could it be????

Reported Mumps Virus Induced Cerebellar Abnormality, The Chari Type 1 Malformation..

http://jvi.asm.org/cgi/content/full/72/10/8037

Virus's can cause Chari??
What about the measles virus..

epithelial cells...

Chiari type I malformation caused by mumps virus..
A cerebellar deformity ...

http://www.ncbi.nlm.nih.gov/pubmed/8171968

A virus can cause this???
What if one has never had the mumps or measles but only the vaccinations???

IGM: IgM antibodies are the type that form when an infection occurs for the first time, high levels of IgM can indicate a new infection is present.

But when it is in the brain..
What does this mean when one has IGM Immunostaining To Brain Endothelial Cells..
Yet only had vaccinations but never caught the mumps or measles??
What does one have when they have IGM Immunostaining To Brain Endothelial Cells and a Chari One Malformation..
Could it be???

Biological VS Environmental Factors

Even though this wants to make a case for a genetic cause it does show the relationship between alot of so called different disorders and makes a case for a probable mercury or environmental trigger.
That genes react to environmental stimuli. If you read between the lines of what this is saying there are clues in there of could be..
Biological and environmental triggers toxins induced can cause a train wreak. I think it did others want to try to prove not.

http://docs.google.com/viewer?a=v&q=cache:geSbMGou3_EJ:jsaw.lib.lehigh.edu/include/getdoc.php%3Fid%3D1994%26article%3D981%26mode%3Dpdf+mecp2+9+mutations+caused+by+mercury&hl=en&gl=us&pid=bl&srcid=ADGEESi9LuG3bd-jCcUabJHYTAipajIr7uk02A_mnMEwtHHjr1Ipp56Tvjs-q8DgiJTQt3Pa6_euZdyhMffbCq50Rx4kaZ4Zjst5uZesBI8zpTwFtzh9Uxa9WHTji2jOtbuR-ewn2I4x&sig=AHIEtbQBwUAti3PNsWozacAusr34io0xBA

Thats a long link...

The study is Biological versus Environmental Factors:
Determining the Cause of Pervasive Developmental Disorders in Children by Jami Zaretsky
Lehigh University
Interesting reading but whats also is interesting is in Chiari one osteoporosis may lead to the development of CM and also reading about rickets.
Rickets can too.

http://www.springerlink.com/content/2gj3d71gjk4g8hlu/

Plus read someone mention Arthritis too..