25 mg is often still too much for many people. 12.5 mg should be ok. 3 days is now the recommended amount of time with the low starting dose, because so many people cannot handle higher dosing or long periods of time.

Andy used to recommend 50 mg, every 4 hours, for one week on, and one week off. But so many people could not handle this, so things have changed to accommodate those who are very toxic.

So typically now it's 12.5 mg, for 3 days on and then 3 days or more as a break and repeat this cycle. You may find over time that you can handle higher dosing and/or longer chelation rounds. But never make yourself go through more than you have to. This is simply about making things more comfortable for you as you reduce the blood levels of mercury. It is not mean to be agony!

A certain amount of symptoms may occur anyway, especially if you are REALLY toxic, but it should not be intolerable. If it is? Dose maybe too high, round maybe too long, OR in some cases, a person may have to take the doses even MORE often if they are a fast metaboliser. So 4 hours may have to be changed to every 3 hours. It depends how fast you use up the DMSA.

So a certain amount of experimentation maybe necessary to reach a point where things are more tolerable.

Believe it or not, there are some people who have had symptoms on 6 mg or less of DMSA, that how mercury toxic they are and how careful they must be with going slow and low.