chelators themselves(ALA, DMSA) will not deplete the minerals, but the mercury that it moves around will. Mercury will deplete Magnesium, Zinc, and probably a few others, which is why Andy includes them in the list of basic supplements that one needs to take when chelating. Mercury really screws up our body's mineral transport system so this is why a lot of minerals are necessary when you are mercury poisoned.

Have you been taking the basic supplements while chelating (C, B vitamins, Mag, Zinc, etc?) What dosages have you been doing? You are taking it every 3 hours around the clock for at least 3 days at a time correct?