Alex, is he still taking licorice root? That helps mood. I recently added carnitine to my regimen. That helps with fat metabolism and cognitive problems. Magnesium also helps with mood. I also like the idea of eating plenty of horseradish, cayenne pepper and garlic on my food. Horseradish and garlic are very high in sulphur, which helps detoxification.

Chelating with ALA improves my mood, but often makes my muscle ache worse. it is strange combination to feel better cognitively but have worse muscle ache.

Some people get mood improvement from St. John's Wort, although I found that St. John's Wort became less effective over time. Licorice root also helps with detoxification.

Alex, has your brother done a parasite cleanse? Some people feel much better after doing a one month cleanse. The herbs used in a parasite cleanse-wormwood, black walnut green hull extract, and cloves are also very antifungal.