Participants in evofaith will regret reading The Implausibility of Metabolic Cycles on the Prebiotic Earth Others may appreciate the information and the perspective from which it comes.

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This paper was submitted on behalf of Leslie Orgel, after his death on 27 October 2007, by Gerald Joyce, The Scripps Research Institute, La Jolla, California, United States of America.


I recommend taking a look directly at what he wrote, and there's been some good commentary as well.

The best, IMO, is found here.
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A veteran origin-of-life researcher died last October: Leslie E. Orgel of the Salk Institute for Biological Studies. Orgel had co-authored Origins of Life on the Earth (1973) with Stanley Miller, the man whose spark-discharge experiment launched the modern origin-of-life craze in the 1950s (05/02/2003). Orgel worked in the field for decades and was familiar with all the different approaches.

Apparently Orgel was working on an essay when he died. Gerald Joyce [Scripps Institute], who wrote a eulogy to Orgel in Nature last November (11/29/2007) submitted Orgel’s manuscript to PLoS Biology. It was published posthumously this week on January 22. Origin-of-life [OOL] researchers will not find much encouragement in Orgel’s last scientific will and testament. It bears careful reading, however, coming from someone who spent a lifetime working on and thinking about chemical evolution.


I would also suggest
http://www.evolutionnews.org/2008/02/leslie_orgel_metabolic_origin.html

http://www.evolutionnews.org/2008/02/leslie_orgel_metabolic_origin_1.html

http://www.godandscience.org/evolution/replicator_vs_metabolism.html

Also, competent readers of the English language who read Orgel's piece may be surprised to find out he meant the opposite of what he actually said. Funny how openly one's intelligence is insulted by the propagandists. Funny, but not really surprising...

Dark Matter + Dark Energy = Dark Truth

"We find that such evidence demonstrates that the ID argument is dependent upon setting a scientifically unreasonable burden of proof for the theory of evolution." - Judge Jones Kitzmiller case
http://www.talkreason.org/articles/Falsify.cfm

"To Compel A Man To Furnish Funds For The Propagation Of Ideas He Disbelieves And Abhors Is Sinful And Tyrannical." - Thomas Jefferson

"And can the liberties of a nation be thought secure when we have removed their only firm basis, a conviction in the minds of the people that these liberties are the gift of God? That they are not to be violated but with his wrath?" - Thomas Jefferson