ALA is for chelation of mercury throughout the entire body. It can chelate mercury from the brain, but OSR can possibly do that as well. OSR still suffers the same drawback as any chelating agent, which is redistribution of the mercury that is not excreted. The problem is we don't know how fast OSR is metabolized so we don't know the optimum schedule to take it to avoid redistribution.

Since ALA can cross the blood brain barrier, if the body levels of mercury are very high, ALA can actually carry mercury into the brain. It naturally diffuses mercury in areas of high concentration to areas of low concentration. If you have low body levels of mercury it will pull mercury out of the brain. For this reason ALA should not be used until 3 months after Mercury Fillings are removed or any other acute exposure to mercury. If OSR can cross the blood brain barrier, the same holds true for it, meaning if the body levels of mercury are too high, more mercury will actually go to the brain, which is very bad. Cilantro seems to be able to cross the blood brain barrier as well.

DMPS and DMSA do not remove mercury from the brain, or the organs. It will only remove extracellular mercury, and will not actually enter any of your cells, it just stays in your blood. They are useful by themselves following Andy Cutlers frequent dose protocol right after exposure to mercury, and also useful in combination with other chelating agents later on. They(DMPS, DMSA) reduce the symptoms you would get from ALA when you take them together, and also reduce the total amount of time needed to chelate when used in this manner since mercury is excreted more efficiently.