Its because the mercury will redistribute, making you feel off, and making it very hard to continue the round. A late dose does not fix this because ALA will move through the entire body and it has no way of targeting the mercury that just got redistributed as opposed to the mercury scattered all throughout your body. You will also notice more symptoms than usual after stopping for the second time as well.

I say just see it as a lesson learned. An hour is the latest you should miss a dose by. I was dosing at 4 hours at night, which Andy says is OK, but switched to 3 hours because it really does make a difference to how I feel, and I actually sleep better dosing at 3 hours.