Russ, if you can tolerate so much vitamin E that is good, however I suggest that people be careful when taking it, and start out at a small dose and then perhaps raise it slowly, but cut back on the first sign of nosebleeds, blood in the stool, or long clotting times when one gets a cut. I guess I could probably take up to 200 IU a day of vitamin E supplements a day safely enough, however I am afraid to get back to the 400 IU or higher dosage level. Perhaps I should be taking 200 IU a day of vitamin E?