Cutler says the time release ALA does not release the ALA evenly and so you get peaks and troughs. You need a constant/stable level of chelator and the flucations will bugger you up. He recommends nobody uses time release ALA because you will get hurt. I have never tried it, but i believe those people that did try it found the side-effects unpleasant. if you search Yahoo FDC you will find many posts.

I dose every 3 hours at night, so i have to wake 2 times. once you get in the mode it is easy and I fall back to sleep again in seconds. You do need to have a system. i need to get out of bed otherwise i turn the alarm off in my sleep.