Stuart, what dosage of ALA have you used? Did you use it with DMSA? I did 6 weeks of chelation using 50 mg ALA every 3 hours, 3 days on 4 off. The first 4 weeks went well, but the last two weeks were horrible. When I start chelation again, I plan to use just 25 mg of ALA.

Licorice root can help quite a bit with depression. Many people have trouble tolerating St. John's Wort.