4 times a day is a bit much admittedly. I would opt for 3 if possible. I'm only passing on what Cutler has said and studied, particulary in mercury toxic people and why they need to take them more often for effectiveness. The only ones that need to be taken that often appear to be the vitamin C, B vitamins, milk thistle and magnesium. The rest do not. It is worth the inconvenience in my opinion to get much more out of what you are taking if what he says is accurate.

I'd imagine it is, I have heard before that people have found his advice almost spot on.

Yeah, depending on whether the supplement needs to be taken with food or not makes a difference. But even if the person has a snack, it's better than nothing. I have taken them 3 times a day before and personally I didn't find it a big deal. And I did notice it made a difference. Sometimes I had to take it a bit later than normal or have a bit of food with it, but no big deal. I failed sometimes, but just got back on track again.

I find the protocol of taking DMSA every 4 hours around the clock far more of an inconvenience than taking vitamins 3 or 4 times a day. But again that too is necessary for the reasons Cutler has given and inconvenience is better than the alternative.