Hi Sunshine,
I've been taking supplements for 10 months and during that time have gone a couple of weeks here and there without supplements and I've felt zero difference. The only thing that makes a noticible difference is fish oil - my skin feels softer when I take that, and the obvious niacin flush. Apart from that i've not noticed a difference whether taking or not taking supplements. I suppose that doesn't mean that they are not doing anything. I intend to continue taking them for now as i have high copper that needs to lowered. Interested to hear how you do.