Thanks very much for that Mikey. Now I know for sure that I really have had adrenal fatigue (and too low cortisol), and that B5 is a powerful supplement to address this problem. My adrenals never overshoot, no matter if I take large doses of B5. I think your overreaction to it may be a result of your anti-depressant usage, they tend to make your adrenals to produce too much cortisol, and leave them in a bad state, that takes a long time to recover from.