I think I've done around 16 rounds, various drugs (DMPS or DMSA w/ALA). In the beginning I did great, when I got to the 6 month post amalgam removal I had an organ dump and was really ill for two months and did not chelate during that time. I then tried the DMPS challege to see where I was at and realized DMPS is just too strong for me and switched back to DMSA. I also realized I don't need big amounts to get the mercury out, so I bumped it down from 50 mgs to 25 mgs DMSA and 12.5 ALA. These seems to be the dosage that I can still function, although I can only make it through a day and a half and then I am pooped so I just do two days on and wait approximately 1 to 2 weeks between rounds depending upon energy levels. I figure if I keep plugging along its better than getting slammed so hard I can't do anything. Right now I am also seeing a specialist I got off this link http://www.geocities.com/chrisgj@sbcglobal.net/Recommended_doctors.html to help me with the fatigue because after reading about chronic fatigue, etc. I am 100% sure I'm treating the thyroid wrong and suspicious about a virus that might be lurking.