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Sregan, are you a sufferer of CFS (chronic fatigue syndrome) or something similar? For them regularly nothing usually works, which is a bit disappointing. I know this from before.
Regarding the dose splitting, I don't think you will have any benefits from B5 if you're not feeling anything with that megadose. The dose splitting is just to make it more effective, take less, but more often.

One addition to the previous message: acetaldehyde is known also to cause a metallic taste in mouth. This sure sounds familiar to me.

PGM,

Yes CFS for over 4 years and I concur nothing has seemed to work regularly for me although I am getting better results now that I am aware of mercury and how it can explain some of the results I've had with certain supplements and why I can feel better for a few days than worse again.

Regarding dose splitting, I've read that things like ALA have a short half life in the body and are better to supplement small amounts more frequently. I know I've been getting GOOD results taking my 80mcg of selenium before bed which is helping me sleep quite a bit instead of in the morning.