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Joined: Dec 2007
Posts: 156
Graduate Member
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http://www.cancertutor.com/Autism/ComprehensiveGuide.docSome very good information on supplements as well as mercury and such. [quote]Chelation with DMSA needs GSH or NAC to metabolize out as disulfide-bound DMSA-GSH or DMSA-NAC. If replacement NAC/GSH is not supplied, DMSA and DMPS (3-4 times more so than DMSA) consume available stores leaving a dangerous deficiency. In humans, oral glutathione is readily absorbed by the gut mucosa, repleting its glutathione supply; but all remaining GSH is then broken down by the mucosa preventing systemic absorption. This may explain why oral glutathione has been of help to autistic children even when there is apparently no systemic absorption. This being true, one must support the body in its manufacture of GSH to avoid a dangerous lack due to chelation. Nevertheless, given the gut dysfunction found in many autistic children, oral glutathione at 250 - 500 mg/day may be of significant help. Additionally, a glutathione cream has become available. I think this means of replenishment of cellular glutathione is highly desirable. Further, it seems both forms should be used. An important point should be emphasized, however, regarding the potential for DMSA to contribute further to cysteine depletion. Ninety percent of the DMSA absorbed is excreted in the urine as a cysteine-DMSA-cysteine disulfide complex.42 Therefore, between days of oral administration of DMSA it is important to replace cysteine, except in those instances where the child is cysteine toxic. The important point here is that pharmacological doses of cysteine/NAC, in the range of 1500 mg daily, have the potential to exacerbate the adverse neurological effects of toxic metals since it moves mercury into the brain in rats. It is of interest to note that intravenous glutathione removes mercury from the brain.{/quote]
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