Hi, no it does not cross the blood brain barrier to any clinical degree. They did studies on rats to prove it does and rats have a different blood brain barrier than humans, so this is why DMSA was able to remove their brain mercury.

Human beings do not have the easy penetrable blood brain barrier that rats do! So the studies were really not very helpful.

ALA however can and is the way to go for people who are finding improvements with DMSA have reached a point where it's not going any further. USually ALA is the ticket when that happens.

I know someone who detoxed with DMSA, improved but had stubborn symptoms that just would not leave her. She detoxed with ALA and got back to normal.

So I believe Andy. Though taking DMSA and ALA together is probably even more effective than ALA alone, simply because there is the extra chelator in there for a bit more stability and possibly increased detox too. ALA can be used alone though. Just so long as it's 3 months past last amalgam removal and not before.