Yeah, it was really bad the last round of 50 mgs DMPS alone, no ALA. First day was okay...2nd day exhausted and itching like I've never seen before, on my face of all things. Makes me think the Nickel is chelating from the braces I had on 2005/2006. Also, the red rash seems to have moved a little downward so I think it's finally leaving. The L-Glutathione complex seems to be helping this. I am thinking of going back to DMSA (25 mgs), have some laying around and cutting my ALA to 12.5 mgs to see if this is more tolerable. Thanks so much for your support and information. It helps a lot!