hi ange : when I was at my worst and still had 9 amalgams I was not sure if mercury was causing my illness ,I could not take any suppliments and lost about 25 pounds and could not gain any weight ,my wife was freaking out , we though the worst , but I did get better after amalgam removal , I started taking my suppliments in the evening after 6:00 pm and was able to tolerate them better ,still not sure why but at least I can take them now ,I had my amalgams put in about 30 years ago ,so I expect to take a little while to get to 90 - 100% again