Hi Linda, you should be careful when increasing the dose so much. The metal does not come out that much faster but the side effects rise dramatically. I’m pretty sure this applies to DMSA and to ALA as well.
If u do decide to increase the dose so much, and if u do get nasty side effects, then you should reduce the dosage to what was manageable.

I had a look for you on Yahoo FDC and found these:-


RE: [frequent-dose-chelation] Re: Starting chelation today - How it went

I second that emotion. It sounds to me like you're ramping up very fast.
Keep in mind that metal removal increase by the square root of the chelator
dose, NOT proportionally. So there is no reason to risk side effects by
ramping up fast. Here's how Andy put it in an earlier message:
________________________


Give your kid 10 mg of DMSA every 4 hours: and he pees out let us say
3 mcg of mercury a day.

Give him 100 mg of DMSA every 4 hours and he will pee out 10 mcg of
mercury a day.

Of course some mercury is pooped out too, and DMSA doesn't do anything
to that, so increasing dosage by 10 fold doesn't even increase
excretion by a factor of 3, it is more like 2 times.

Side effects on 10 mg, low.

Side effects on 100 mg, horrendous.

Is this clear, or should I talk about it more?

Andy . . . . . . . . . . . . . .
http://health.groups.yahoo.com/group/frequent-dose-chelation/message/20443


The amount of metals that come out go more or less as the square root
of the dose. 4X the dose, twice as fast. 9 X, three times as fast.
The side effects go up linearly or worse with dose. Thus the side
effects become dramatic but the metals don't come out much faster.
This is why you want to use a lower dose - the metals come out almost
as fast as at higher dosages, but with MUCH less suffering.

http://health.groups.yahoo.com/group/Autism-Mercury/message/36193

If the rounds are too hard on you, the best solution would be to reduce the
dose until the side effects are tolerable. As Andy has explained, if you
increase the dose tenfold, you're only eliminating about twice as much
metals. So don't underestimate the power of really small, frequent doses.
I'm 180 pounds and have been pleasantly surprised at how well 12.5 mg every
3 hours works for me, with minimal side effects.

http://health.groups.yahoo.com/group/frequent-dose-chelation/message/20449

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