That would be a tough choice. Some days the fatigue is the worst problem. Other days the muscle ache is. Other times the chemical sensivity is really dragging me down, and exposure to fragrances, cigarrette smoke, diesel fumes, etc. might trigger a headache, inense muscle ache, or great fatigue. I might be feeling good, then exposure to something I am sensitive to really drags me down. I need to avoid large indoor crowds for this reason.