hi Kriminal, sure .....

I take 500 - 1000 mg of the L-Tryptophan in the evening before bed. I'll take two caps (1000 mg) if I think I have too much energy because it helps me sleep. I also use how I've felt during the day as a gauge on whether I take 1 or 2 caps in the evening. My doc told me to also take it with a light snack that has a healthy fat as this will help facilitate with the serotonin uptake. So I take it with some nuts or some liquid Udo's oil or something.

The B6 I'm taking is actually B6 phosphate by Biotics Research. I'm female and I don't know whether that makes a difference or not in B6 levels. But the B6 is also meant to help in keeping estrogen dominance away. The B6 is 20 mg. caplets and I take 2 a day in divided doses (that is, 1 in the am/ and 1 in the pm). This is in addition to the B6 is that is in daily multi.

I was afraid to be taking so much B6 because I understand it can cause serious and permanent nerve damage if one takes too much. My doc said it's fine to take higher doses when under the care of a practitioner or doc. So far I've been doing this for 8 months and I'm doing just fine.

The magnesium has been a little difficult. Most people have a hard time assimilating and digesting mineral supplements. I could not take tablets -- I just passed them whole. And whether it was my irritable bowel problems or what -- I don't know -- but it was hard for me to take alot of magnesium without IBS flare-ups.

My doc recommended Magnesium Glycinate -- he said his experience was that it was a better absorbed form of mag. for most folks. I'm taking the brand that Metagenics makes. Although it's in capsule form, I grind it up and swallow the powder. The tablets come in 200 mg doses.

Most days I take 1 of those -- but I was told to take more if needed. There is also magnesium in my cal/mag supplement and my multi. So now I'm getting an approximate total of 1100 mg of magnesium. My doc would like me to take more magnesium glycinate -- but my bowels just get too irritable with more. Sorry if that's too much information!

I had my amalgams removed about a year ago but I have not been able to do any formal chelation because of underlying infections (Mycoplasma) and very tired adrenal glands. My body just doesn't have the metabolic energy right now to formally chelate.

Anyway, I think the entire neurotransmitter issue is worth pursuing for folks who have anxiety, depression, etc. What I listed is what worked for me in my case. But I understand that there are different combinations of deficiencies that can exist (i.e., dopamine deficiencies, GABA, etc.) and those can still cause anxiety/depression.

That's why I included that last website above. I've never used their services nor have I ever ordered from them. But I think the information they have is helpful. And it's interesting to see the integrative approach they're using with innovative testing and supplementation to try and help folks.

I have still my moments like everyone else. But I must say that the improvements were indeed virtually overnight when I began that extra supplementation.

So, in summary:

500-1000 mg of L-Tryptophan
140 mg of B6 (this is a lot! and probably shouldn't be supplemented at this level without the advice of a physician or a known deficiency is shown by testing)
1100 mg. of Magnesium

Hope this helps.