Double blind studies on antidepressants show that they have very little effect. but numerous side effects . Any improvement in mood tends to be in the second decimal place.One side effect ,dry mouth, makes one far more prone to tooth decay resulting in more hg exposure root canals chronic pain etc.Another fairly serious side effect is death from irregular heart beat.I think this is what killed Anna Nicole Smith"s son . In the monthes before he died , he went to doctors several times complaining of heart beat irregularities. When he died he had 10x the expected amount of antidepressant in his body fluids and even more in his tissues.Like hg , different people excrete drugs at different rates, because of differences in cytochromes.Tissue levels are often far higher than blood levels as is the case with mercury.