Thanks again for the update.

Yes will look into topical but decided to lay off the st johns wort for a while.

I took B3 as Niacinamide which is different to niacin as that would be crazy with the flushes lol. Yes I read later that its used for schizophrenia.

Will have to look out for that book.
Yeh your right about the biochemical indiviuality. Sometimes I expect or think too much about what im taking though so I dont know whats real or placebo etc..its so confusing and a really bad habit self supplementing and I have got to stop.