I had thyroid surgery 50% removed... it was BIG.. though all blood tests showed hormone levels good. A couple months later the hormones were down a bit and I was starte on 50 mcg of T4. Within 1 day it was pure hell with every kind of physcial and emotional symptoms. They would come and go for minutes or days at a time. Inceases in T4 and adding T3 didn't help. I had 6+ months of that and within a day of my first dose of hydrocortisone I felt good. Well, not good good, but good compared to the last 6 months. Continuing the HC and changing to the equvivelent of Armour got me to the "functional" stage where I am now.