I'm glad you brought up the niacin! There are some people (like me) who have overactive liver phase I and underactive liver phase II. This can be caused by mercury toxicity or long term other toxicity or apparently "genetic uniqueness". people with this are usually chemically sensitive and can suffer panic disorders also.

The worst things you can do with this is to take things that speed liver phase I up even more. B3 in the form of Niacin is one of those things and should be avoided. The other form of B3 Nicatinamide (or niacinimide) is the best one to use and actually helps slow liver phase I down! Which is what a person in that situation wants.

So maybe that might be part of this? if liver phase I is functioning too fast, it works by overloading liver phase II. Liver phase I being overactive also makes toxic compounds even more toxic, then liver phase II can not keep up, so the body cannot eliminate toxins properly.