The toxicity does not occur when Cortef is given in physiological doses -- as is done in treating Adrenal Fatigue. See, "The Safe Uses of Cortisol," by Dr. William Jeffries for established studies and efficacy as well as safety.

Cortisone when given in large doses (i.e., not small physiological doses) can be problematic when taken over long periods. However, as stated above, when treating Adrenal Fatigue, only physiological doses are used.