Well from a personal perspective, if you are going to see a psychiatrist for clinical depression, try 3 or 4 different antidepressants at the most, if no progress, move on. I stayed too long because i didn't have the knowledge that i now have. Also had ECT. If it's biological depression, which the sufferer should be able to determine through common sense, i would steer away from psychotherapy, CBT etc, because its total bullshit. It's well documented the psychiatric disturbances that mercury causes, add to that fungal issues which hang around with their heavy metal friend, and parasites which starve the brain of nutrients. I would estimate that there are millions of mentally ill patients who have toxins coming out of their ears, and god knows how many of them don't realise it. I myself have nothing in my life to drag me down, keep me isolated at home every day, so it's clearly a biological/toxicolgical situation. Poisons have the ability to completely alter a persons thoughts and emotions, and its destructive beyond words because the person can beleive its really them, when it's not.