Yes it does sound like classic die-off symptoms to me. the important thing to remember is that die off is not necessarily good for you if you are experiencing it long term. You should aim to go at your maximum dosage without experiencing so much discomfort while on the stuff.
Also, you could look into a sluggish liver. As this could contribute to major die off symptoms with "normal" dosages of antibaterials/antifungals/antivirals. If your system is not eliminating the wastes as quickly as it should perhaps you should add some liver support. (with a general immune stimulant to clear all that dead stuff from your system). Some naturopathic doctors call it "weed and feed".