Hi, my issues are severe brain fog and moderate fatigue. I did DMSA+ALA (Cutler protocol) and some EDTA suppositories for about 4 months, then went all out and did weekly IV's alternating DMPS and EDTA, glutathione shots, replenish minerals, etc. for 1 year. I haven't had amalgams but there is always exposure to mercury and I have bad genes for detox (APOE 3/4, null GSTM, null GSTD). I kept at it because it seemed to reach at the problem - I felt badly for 4-5 days but then there was a window period of my brain fog clearing up ..... but overall my health was declining. Now I am thinking the 4-5 days period was stirring up of bacteria sequestered with metals (symptoms included fever) giving my immune system a chance to kill some of them off.