i believe it does not pull mercury out of tissue, but does clean up mercury in your blood - it traps mercury that is in fluid in its cage-like structures. Someone earlier on this discussion called it a passive chelator. All I know is that two dentists recommended that I take it with my amalgams in first- and they are both mercury free dentists who follow proper protocol with good reputations. I posted messages on the NCD yahoo message board and multiple people confirmed the same thing -they said it is safe to take with amalgams in.