My dentist, and the company making NCD, both claim that NCD is safe even with amalgams in. My dentist wants me to try to get on to NCD before removing amalgams as a measure of safety. He wants to make sure that if I get almalgams removed, there will be something I can tolerate that will remove the mercury from my body. Because I am so sensitive, I am afraid to just remove the amalgams with the chance that I cannot tolerate chelating at all. I have read in several places that you can take this with amalgams in, but it is recommended to get them removed so that you can complete the job without continuing to be poisoned.