Cutler discusses this in his book briefly. A person with adrenal problems will have a bad tired lull at about 3-4 if he/she forces themselves to stay up past 10 pm they will stay up ALL night. In fact at times they will be extremely tired but not people able to sleep (racing mind, panic, feeling like they can't breath) alot of this is caused by adrenal and the subsequent slowdown in cerrulplasim production (in the adrenals) and there for causing a accumulation of copper. Cerrulplasim causes the liver to bind copper into bile and excrete it. Low adrenals, alot of times high copper which accounts for SOME (not always) of the psycological problems. Mercury directly effects a enzyme that will allow you to make normal (or high) progestrone and normal/high DHEA but low cortisol because of the enzyme defciency. Everybody has to remember that Mercury interferes greatly with enzymes, cell receptors and everything under the sun. I think the important thing to account for is that most of us probably have a genetic fault that favors accumlation of mercury. This does not mean that you can't do anything it just means you have to modulate amino acids (taurine for example) minerals (zinc, lower copper, etc) , vitamins (vitamin C)to favor your genetic predisposition along with avoiding mercury exposuire, before, during and after a appropriate chelation method. A good thing to try is Vitamin C and B-5 (panthetic acid) as they are highest in your Adrenals and Pituatary glands. If you have been adrenal insufficent (adrenal fatigue what not) then you may get "copper dumps" from the Vitamin C as it is a great chelator of Copper.