I read that one should keep the ratio of ALA to DMSA between 1:1 and 1:2. So that would mean starting at 12.5mg ALA with 12.5 or 25mg DMSA to be on the safe side. I also make my last dose or two of each cycle DMSA alone to minimize redistribution back into the brain. I buy empty gel caps and divide the ALA and DMSA accordingly. Hope this is helpful!!!