No wonder you feel like you're losing it. That is the highest dose I've heard of anybody using of ALA.

Tell me, did you use DMSA on it's own for a few months before adding ALA? That is crucial. 100 mg of DMSA is very very high on it's own, but 400 mg of ALA has blown me away.

You should be able to stabilise things again if you knock off the ALA and just take DMSA for a time (maybe at lower doses like 25 - 50 mg).

But don't use ALA until you have reduced your blood/tissue levels of mercury, otherwise you risk moving more mercury INTO the brain by using ALA too early. If you haven't already, you need to use just DMSA alone for about 3 months, then later add ALA. But again, at far lower doses than what you've been using.

Of course, you can get the mercury back out again at some point, but you can see the risks.

alpha lipoic acid causes a lot of symptoms/side effects even at relatively low doses, so no wonder you feel over the edge.

I'd concentrate on DMSA for a while and just use moderate doses of it. Maybe 25 mg or so. If you can handle more of it, ok, but definitely don't add ALA until you're ready and then only very small doses to start out. I would never go over 25 mg of ALA, until I was certain I could cope.

You may know all this already and have already done it. And if you have, I'd still go back to DMSA for a while to try and bring things a little back into balance. Adjust the doses down to tolerance.

Your symptoms should start to abate at some point, but you will really feel very unstable for a while. That would flatten anybody!

Hope you improve soon.