yea antihistamine definely work for a short period, but they can make you real drowsy and give u that "drunk" feeling. I couldn't believe how much better I felt when Itook one recently, it gave me such a relief from depression and skin issues, also irritated eyes and so on. But you should only use them in emergencies I think. Also if you find that histamine is a problem for you it is very important to follow diet recommendations until you histamine levels go down.